2017-2020 Publications
2017-2020 Publications
2017-2020 Publications
All Publications
* = co-first author, † = corresponding author
Zhang Y, Naderi Yeganeh P, Zhang H, Wang SY, Li Z, Gu B, Lee DJ, Zhang Z, Ploumakis A, Shi M, Wu H, Greer EL, Hide W, Lieberman J (2024). Tumor editing suppresses innate and adaptive antitumor immunity and is reversed by inhibiting DNA methylation. Nat Immunol. Oct;25(10):1858-1870. doi: 10.1038/s41590-024-01932-8. Epub 2024 Aug 21. PubMed PMID: 39169233.
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Fontana P, Du G, Zhang Y, Zhang H, Vora SM, Hu JJ, Shi M, Tufan AB, Healy LB, Xia S, Lee DJ, Li Z, Baldominos P, Ru H, Luo HR, Agudo J, Lieberman J, Wu H (2024). Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity. Cell. Sep 2;. doi: 10.1016/j.cell.2024.08.007.
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Zhang E, Healy L, Du G, Wu H (2024) Cleavage-independent GSDME activation by UVC. Nature Cell Biology. July; 26(9):1377-1379. doi: 10.1038/s41556-024-01470-3.
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Dong Y, Bonin JP, Devant P, Liang Z, Sever AIM, Mintseris J, Aramini JM, Du G, Gygi SP, Kagan JC, Kay LE, Wu H (2024 ). Structural transitions enable interleukin-18 maturation and signaling. Immunity. 2024 Jul 9;57(7):1533-1548.e10. doi: 10.1016/j.immuni.2024.04.015. Epub 2024 May 10.
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Fu J, Schroder K, Wu H (2024 ). Mechanistic insights from inflammasome structures. Nat Rev Immunol. Jul;24(7):518-535. doi: 10.1038/s41577-024-00995-w. Epub 2024 Feb 19. Review. PubMed PMID: 38374299; PubMed Central PMCID: PMC11216901.
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Bonin JP, Aramini JM, Dong Y, Wu H, Kay LE. (2024). AlphaFold2 as a replacement for solution NMR structure determination of small proteins: Not so fast!. J Magn Reson. Jul;364:107725. doi: 10.1016/j.jmr.2024.107725. Epub 2024 Jun 19. PubMed PMID: 38917639.
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Du G, Healy LB, David L, Walker C, El-Baba TJ, Lutomski CA, Goh B, Gu B, Pi X, Devant P, Fontana P, Dong Y, Ma X, Miao R, Balasubramanian A, Puthenveetil R, Banerjee A, Luo HR, Kagan JC, Oh SF, Robinson CV, Lieberman J, Wu H (2024). ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature. 2024 Jun;630(8016):437-446. doi: 10.1038/s41586-024-07373-5. Epub 2024 Apr 10. PubMed PMID: 38599239; PubMed Central PMCID: PMC11283288.
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David L, Borges JP, Hollingsworth LR, Volchuk A, Jansen I, Garlick E, Steinberg BE, Wu H ( 2024 ). NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks. Cell. Apr 25;187(9):2224-2235.e16. doi: 10.1016/j.cell.2024.03.008. Epub 2024 Apr 12. PubMed PMID: 38614101; PubMed Central PMCID: PMC11055670.
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Balasubramanian A, Hsu AY, Ghimire L, Tahir M, Devant P, Fontana P, Du G, Liu X, Fabin D, Kambara H, Xie X, Liu F, Hasegawa T, Xu R, Yu H, Chen M, Kolakowski S, Trauger S, Larsen MR, Wei W, Wu H, Kagan JC, Lieberman J, Luo HR (2024). The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis. Sci Immunol. Apr 12;9(94):eadn1452. doi: 10.1126/sciimmunol.adn1452. Epub 2024 Apr 12. PubMed PMID: 38530158; PubMed Central PMCID: PMC11367861.
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David L, Borges J, Hollingsworth L, Volchuk A, Jansen I, Garlick E, Steinberg B, Wu H (2024). NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks. Cell.. April; 187(9):2224-2235.e16. doi: 10.1016/j.cell.2024.03.008.
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Fu J, Schroder K, Wu H (2024). Mechanistic insights from inflammasome structures. Nature Reviews Immunology. February; 24(7):518-535. doi: 10.1038/s41577-024-00995-w.
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Yan Y, Xiao J, Huang F, Xian W, Yu B, Cheng R, Wu H, Lu X, Wang X, Huang W, Li J, Oyejobi GK, Robinson CV, Wu H, Wu D, Liu X, Wang L, Zhu B .Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway. Nat Microbiol. 2024;9(6):1566-1578..
​Tan T, Gao B, Yu H, Pan H, Sun Z, Lei A, Zhang L, Lu H, Wu H, Daley GQ, Feng Y, Zhang J Dynamic nucleolar phase separation influenced by non-canonical function of LIN28A instructs pluripotent stem cell fate decisions. . Nat Commun. 2024;15(1):1256.
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Wang Y, Hollingsworth LR, Sangaré LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ. I, Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity.
mBio. 2024 15 (3) e0330223.
Li R, Zan Y, Wang D, Chen X, Wang A, Tan H, Zhang G, Ding S, Shen C, Wu H, Zhu S (2024). A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions. Proceedings of the National Academy of Sciences. January; 121(6):-. doi: 10.1073/pnas.2321419121.
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Devant P, Dong Y, Mintseris J, Ma W, Gygi SP, Wu H, Kagan JC (2023). Structural insights into cytokine cleavage by inflammatory caspase-4. Nature. Dec;624(7991):451-459. doi: 10.1038/s41586-023-06751-9. Epub 2023 Nov 22. PubMed PMID: 37993712; PubMed Central PMCID: PMC10807405.
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Cai T, Lenoir Capello R, Pi X, Wu H, Chou J (2023 ) Structural basis of γ chain family receptor sharing at the membrane level. Science. August; 381(6657):569-576. doi: 10.1126/science.add1219.
Healy LB, Du G, Wu H. (2023) Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens. Trends Immunol. Aug;44(8):571-573. doi: 10.1016/j.it.2023.06.006.
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Du G *, Zhao L, Zheng Y, Belfetmi A, Cai T, Xu B, Heyninck K, Van Den Heede K, Buyse MA, Fontana P, Bowman M, Lin LL, Wu H†, Chou JJ† (2023) Autoinhibitory (2023) Structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation. Cell Res. Feb;33(2):131-146
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Li J*, Wang L*, Hahn Q, Nowak R , Viennet T, Orellana E, Burman S, Yue H , Hunkeler M, Fontana P, Wu H, Arthanari H, Fischer E, Gregory R.† . (2023) Structural basis of regulated m7G tRNA modification by METTL1-WDR4. Nature. Jan 4th, doi 10 1038/s41586- 022005566-4
Xiao L*, Magupalli VG, Wu H† (2022) Cryo-EM structures of the active NLRP3 inflammasome disk​ Nature. doi: 10.1038/s41586-022-05570-8.
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Dong Y *, Pi X*, Bartels-Burgahn F, Saltukoglu D, Liang Z, Yang J, Alt FW, Reth M, Wu H† (2022) Structural principles of B cell antigen receptor assembly Nature. 612(7938):156-161.
Sun Z*, Yu H, Zhao J, Tan T, Pan H, Zhu Y, Chen L, Zhang C, Zhang L, Lei A, Xu Y, Bi X, Huang X, Gao B, Wang L, Correia C, Chen M, Sun Q, Feng Y, Shen L, Wu H, Wang J, Shen X, Daley GQ, Li H, Zhang J. (2022) LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells. ​Protein Cell. Jul;13(7):490-512. doi: 10.1007/s13238-021-00864-5.
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Fontana P*, Dong Y *, Pi X*, Tong AB, Hecksel CW, Wang L, Fu TM, Bustamante C, Wu H† (2022) Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold. Science. Jun 10;376(6598):eabm9326. doi: 10.1126/science.abm9326.
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Xia M*, David L, Teater M, Gutierrez J, Wang X, Meydan C, Lytle A, Slack GW, Scott DW, Morin RD, Onder O, Elenitoba-Johnson KSJ, Zamponi N, Cerchietti L, Lu T, Philippar U, Fontan L, Wu H† Melnick AM†. (2022) BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL. Cancer Discov. Aug 5;12(8):1922-1941. doi: 10.1158/2159-8290.CD-21-1566
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Junqueira C*, Crespo Â, Ranjbar S, de Lacerda LB, Lewandrowski M, Ingber J, Parry B, Ravid S, Clark S, Schrimpf MR, Ho F, Beakes C, Margolin J, Russell N, Kays K, Boucau J, Das Adhikari U, Vora SM, Leger V, Gehrke L, Henderson LA, Janssen E, Kwon D, Sander C, Abraham J, Goldberg MB, Wu H, Mehta G, Bell S, Goldfeld AE, Filbin MR, Lieberman J†. (2022) FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation. Nature. Jun;606(7914):576-584. doi: 10.1038/s41586-022-04702-4.
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Zheng W*, Shen C, Wang L, Rawson S, Xie WJ, Nist-Lund C, Wu J, Shen Z, Xia S, Holt JR, Wu H†, Fu TM. (2022) pH regulates potassium conductance and drives a constitutive proton current in human TMEM175. Sci Adv. Mar 25;8(12):eabm1568. doi: 10.1126/sciadv.abm1568
Vora SM*, Fontana P, Mao T, Leger V, Zhang Y, Fu TM, Lieberman J, Gehrke L, Shi M, Wang L, Iwasaki A, Wu H†. ( 2022 ) Targeting stem-loop 1 of the SARS-CoV-2 5' UTR to suppress viral translation and Nsp1 evasion. Proc Natl Acad Sci USA. 119 (9). Doi: 10.1073/pnas.211719819
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Meza-Sosa KF*, Miao R, Navarro F, Zhang Z, Zhang Y, Hu JJ, Hartford CCR, Li XL, Pedraza-Alva G, Pérez-Martínez L, Lal A, Wu H† Lieberman J † (2022) SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage. Mol Cell. Feb 17;82(4):785-802.e10. doi: 10.1016/j.molcel.2022.01.001.
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Xie WJ*, Xia S, Warshel A, Wu H† ( 2022 ) Electrostatic influence on IL-1 transport through the GSDMD pore. ​Proc Natl Acad Sci U S A. 8;119(6). doi: 10.1073/pnas.2120287119
Deng W *, Bai Y, Deng F, Pan Y, Mei S, Zheng Z, Min R, Wu Z, Li W, Miao R, Zhang Z, Kupper TS, Lieberman J†, Liu X†. ( 2022 ) Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature. doi: 10.1038/s41586-021-04384-4.
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Gao W *, Li Y, Liu X, Wang S, Mei P, Chen Z, Liu K, Li S, Xu XW, Gan J, Wu J, Ji C, Ding C, Liu X, Lai Y, He HH, Lieberman J, Wu H†, Chen X, Li J. ( 2022 ) TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization. Cell Death Differ. 29(2):439-450.
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Wang L*, Crackower MA ,Wu H.†.(2022). Advances toward structure-based drug discovery for inflammasome targets. J Exp Med. Jan 3219(1). doi: 10.1084/jem20211147. Epub 2021 Nov 16. PubMed PMID: 34783859
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Andreeva L*, David L, Rawson S, Shen C, Pasricha T, Pelegrin P, Wu H.†. (2021). NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation. Cell. 184(26):6299-6312.
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Shen C*, Li R*, Negro R, Cheng J, Vora SM, Fu TM, Wang A, He K, Andreeva L, Gao P, Tian Z, Flavell RA, Zhu S†, Wu H.†.(2021). Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome. Cell. 184 : 1–16 .
Vora SM*, Lieberman J, Wu H† (2021). Inflammasome activation at the crux of severe COVID-19. Nat Rev Immunol. 21(11): 694-703.
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Magupalli VG†, Fontana P, Wu H† (2021). Ragulator-Rag and ROS TORment gasdermin D pore formation. Trends Immunol. 42: 948-950.
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Bittner ZA*, Liu X, Mateo Tortola M, Tapia-Abellán A, Shankar S, Andreeva L, Mangan M, Spalinger M, Kalbacher H, Düwell P, Lovotti M, Bosch K, Dickhöfer S, Marcu A, Stevanović S, Herster F, Cardona Gloria Y, Chang TH, Bork F, Greve CL, Löffler MW, Wolz OO, Schilling NA, Kümmerle-Deschner JB, Wagner S, Delor A, Grimbacher B, Hantschel O, Scharl M, Wu H†, Latz E†, Weber ANR†. (2021) . BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity. J Exp Med. 218(11). doi: 10.1084/jem.20201656.
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Fillmore N*, Bell S, Shen C, Nguyen V, La J, Dubreuil M, Strymish J, Brophy M, Mehta G, Wu H†, Lieberman J†, Do N†, Sander C†. (2021). Disulfiram use is associated with lower risk of COVID-19: (2021) A retrospective cohort study. PLoS One. 16(10): e0259061.
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Tong AB, Burch JD, McKay D, Bustamante C, Crackower MA, Wu H. (2021) Could AlphaFold revolutionize chemical therapeutics?. Nat Struct Mol Biol. 28(10):771-772.
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Gao W, Li Y, Liu X, Wang S, Mei P, Chen Z, Liu K, Li S, Xu XW, Gan J, Wu J, Ji C, Ding C, Liu X, Lai Y, He HH, Lieberman J, Wu H, Chen X, Li J. ( 2021) TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization. Cell Death Differ. Sep 11;. doi: 10.1038/s41418-021-00867-z. [Epub ahead of print] PubMed PMID: 34511601.
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Münzer P, Negro R, Fukui S, di Meglio L, Aymonnier K, Chu L, Cherpokova D, Gutch S, Sorvillo N, Shi L, Magupalli VG, Weber ANR, Scharf RE, Waterman CM, Wu H, Wagner DD†. (2021). NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions. Front Immunol 12: 683803
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Wang L, Sharif H*, Vora SM*, Zheng Y, Wu H† (2021). Structures and functions of the inflammasome engine. J Allergy Clin Immunol 147: 2021-2029
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Sharif H*, Hollingsworth LR*, Griswold AR*, Hsiao JC, Wang Q, Bachovchin DA†., Wu H†. (2021). Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. Immunity 54: 1-13
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Andreeva L, Wu H (2021). STING condensates on ER limit IFN response. Nat Cell Biol. 23: 299-300
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Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu T-M, Jacobson MP, Greka A, Lieberman J, Ruan J, Wu H† (2021). Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature 593: 607-611
Hollingsworth, L.R.*, Sharif, H.*, Griswold, A.R.*, Fontana P., Mintseris J., Dagbay K.B., Paulo J.A., Gygi S.P., Bachovchin D.A.†, Wu H.† (2021) DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature 592, 778–783.
Liu X*†, Xia S*, Zhang Z*, Wu H†, Lieberman J†. (2021). Channeling inflammation: gasdermins in physiology and disease. Nat Rev Drug Discov.
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Shen C*, Vohra M*, Zhang P, Mao X, Figley MD, Zhu J, Sasaki Y, Wu H†, DiAntonio A†, Milbrandt J†. (2021). Multiple domain interfaces mediate SARM1 autoinhibition. Proc Natl Acad Sci USA. 118(4).
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Hollingsworth LR*, David L, Li Y, Griswold AR, Ruan J, Sharif H, Fontana P, Orth-He EL, Fu TM, Bachovchin DA, Wu H† (2021). Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun. 2(1):189.
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Xia S*(2020). Biological mechanisms and therapeutic relevance of the gasdermin family. Mol Aspects Med. doi:10.1016/j.mam.2020.100890.
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Hatcher JM, Yang G, Wang L, Ficarro SB, Buhrlage S, Wu H, Marto JA, Treon SP, Gray NS †(2020). Discovery of a Selective Covalent IRAK1 Inhibitor with Antiproliferative Activity in MYD88 Mutated B-Cell Lymphoma. ACS Med Chem Lett . doi: 10.1021/acsmedchemlett.0c00378
Wang L†, Wu D, Robinson CV, Wu H†, Fu TM† (2020). Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. Mol Cell . doi: 10.1016/j.molcel.2020.09.029
Zhao L, Fu Q, Pan L, Piai A, Chou JJ † (2020). The diversity and similarity of transmembrane trimerization of TNF receptors. Front Cell Dev Biol. doi: 10.3389/fcell.2020.569684
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Magupalli VG*†, Negro R†*, Tian Y*, Hauenstein AV*, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y†, Wu H † (2020). HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science. 18;369(6510)
Hu JJ*, Liu X*, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu H† (2020). FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nature Immunology. doi: 10.1038/s41590-020-0669-6.
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He M*, Chiang HH*, Luo H*, Zheng Z*, Qiao Q, Wang L, Tan M, Ohkubo R, Mu WC, Zhao S, Wu H, Chen D†.(2020). An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance. Cell Metab. 31(3):580-591.
Wang L*, Negro R*, Wu H†(2020). TRPM2, linking oxidative stress and Ca2+ permeation to NLRP3 inflammasome activation. Curr Opin Immunol. 62:131-135.
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Cui Y, Keles S, Charbonnier LM, Julé AM, Henderson L, Celik SC, Reisli I, Shen C, Xie WJ, Schmitz-Abe K, Wu H, Chatila TA† (2020). Combined immunodeficiency caused by a loss-of-function mutation in DNA polymerase delta 1. J Allergy Clin Immunol. 145(1):391-401.
Chen H*, Gu L*, Orellana EA, Wang Y, Guo J, Liu Q, Wang L, Shen Z, Wu H, Gregory RI, Xing Y, Shi Y† (2020). METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing. Cell Res doi: 10.1038/s41422-019-0270-4.
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Lieberman J*†, Wu H*†, Kagan JC*†. Gasdermin D activity in inflammation and host defense. Sci Immunol. 4(39). pii: eaav1447. doi: 10.1126/sciimmunol.aav1447.
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Sharif H*, Wang L*, Wang WL*, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Núñez G, Mao Y†, Wu H† (2019). Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature. 570(7761):338-343.
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Pan L*, Fu TM*, Zhao W*, Zhao L*, Chen W, Qiu C, Liu W, Liu Z, Piai A, Fu Q, Chen S†, Wu H†, Chou JJ† (2019). Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. Cell. 176(6):1477-1489.
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Shen C*, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu TM*†, Wu H*† (2019). Molecular mechanism for NLRP6 inflammasome assembly and activation.. Proc Natl Acad Sci U S A. 25(8):732-742.
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Zhang P*, Fan Y*, Ru H, Wang L, Magupalli VG, Taylor SS, Alessi DR, Wu H*† (2019). Crystal structure of the WD40 domain dimer of LRRK2. Proc Natl Acad Sci U S A. 116(5):1579-1584.
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Wang L*, Ferrao R*, Li Q, Hatcher JM, Choi HG, Buhrlage SJ, Gray NS, Wu H† (2019). Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor–associated kinase 4 (IRAK4). The Journal of biological chemistry. 2019.
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Xia S*, Hollingsworth LR 4th*, Wu H†(2019). Mechanism and Regulation of Gasdermin-Mediated Cell Death. Cold Spring Harb Perspect Biol. pii: a036400. doi: 10.1101/cshperspect.a036400.
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Wu H*, Arnold E* (2019). Michael G. Rossmann (1930-2019) Nat Struct Mol Biol. (8):660-662.
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Wang L, Wu H† (2019). Keeping the Death Protein in Check. Immunity. 51(1):1-2.
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Scott DA*† , Hatcher JM, Liu H, Fu M, Du G, Fontán L, Us I, Casalena G, Qiao Q, Wu H, Melnick A, Gray NS (2019). Quinoline and thiazolopyridine allosteric inhibitors of MALT1. Bioorg Med Chem Lett. 29(14):1694-1698.
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Arnold E†* , Wu H*, Johnson JE*. (2019). Michael G. Rossmann (1930-2019), pioneer in macromolecular and virus crystallography: scientist, mentor and friend. Acta Crystallogr D Struct Biol. 75(Pt 6):523-527.
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Xia S*, Wang L*, Fu TM†, Wu H† (2019). Mechanism of TRPM2 channel gating revealed by cryo-EM. FEBS J. 286(17):3333-3339.
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Xia S, Ruan J†, Wu H†(2019). Monitoring gasdermin pore formation in vitro. Methods Enzymol. 625:95-107
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Shen C, Sharif H, Xia S, Wu H† (2019). Structural and mechanistic elucidation of inflammasome signaling by cryo-EM. Curr Opin Struct Biol. 58:18-25
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Lee YR, Chen M, Lee JD*, Zhang J*, Lin SY*, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, Wan L, Shen C, Hsu CH, Papa A, Clohessy JG, Teruya-Feldstein J, Jain S, Wu H, Matesic L, Chen RH, Wei W, Pandolfi PP† (2019). Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 364(6441).
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Wang L*, Ferrao R*, Li Q, Hatcher JM, Choi HG, Buhrlage SJ, Gray NS, Wu H† (2019). Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). The Journal of biological chemistry. 294(12):4511-4519.
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Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU†(2019). SERPINB1-mediated checkpoint of inflammatory caspase activation. Nature immunology. 20(3):276-287.
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Mompeán M*, Bozkurt G*, Wu H†.(2019). Mimicry by a viral RHIM. EMBO reports. 20(2).
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Wang L*, Fu TM*†, Zhou Y, Xia S, Greka A, Wu H† (2018). Structures and gating mechanism of human TRPM2. Science. 362(6421).
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Li Y*, Fu TM*†, Lu A, Witt K, Ruan J, Shen C, Wu H† (2018). Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1. Proc Natl Acad Sci U S A. 115(43):10845-10852.
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Ru H*, Mi W*, Zhang P, Alt FW, Schatz DG, Liao M†, Wu H† (2018). DNA melting initiates the RAG catalytic pathway. Nature structural & molecular biology. 25(8):732-742.
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Mompeán M*, Li W*, Li J*, Laage S, Siemer AB, Bozkurt G, Wu H†, McDermott AE† (2018). The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex. Cell. 173(5):1244-1253.
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Ruan J, Xia S, Liu X, Lieberman J, Wu H† (2018). Cryo-EM structure of the gasdermin A3 membrane pore. Nature. 557(7703):62-67.
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David L, Li Y, Ma J, Garner E, Zhang X, Wu H† (2018). Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome. Proc Natl Acad Sci U S A. 115(7):1499-1504
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Ru H, Zhang P, Wu H (2018). Structural gymnastics of RAG-mediated DNA cleavage in V(D)J recombination. Curr Opin Struct Biol. 53:178-186.
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Orning P, Weng D1*, Starheim K*, Ratner D*, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, Berger SB, Gough PJ, Bertin J, Proulx MM, Goguen JD, Kayagaki N, Fitzgerald KA, Lien E†.(2018). Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death Science. 362(6418):1064-1069.
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Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C†, Lencer WI †(2018) INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. eLife. 2018; 7.
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Fontán L*†, Qiao Q, Hatcher JM, Casalena G, Us I, Teater M, Durant M, Du G, Xia M, Bilchuk N, Chennamadhavuni S, Palladino G, Inghirami G, Philippar U, Wu H, Scott DA*, Gray NS, Melnick A*† (2018). Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth. The Journal of clinical investigation. 128(10):4397-4412.
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Feltham R*, Jamal K*, Tenev T*, Liccardi G, Jaco I, Domingues CM, Morris O, John SW, Annibaldi A, Widya M, Kearney CJ, Clancy D, Elliott PR, Glatter T, Qiao Q, Thompson AJ, Nesvizhskii A, Schmidt A, Komander D, Wu H, Martin S, Meier P† (2018). Mind Bomb Refulates Cell Deth during TNF Signalling by Suppressing RIPK1’s Cytotoxic Potential. Cell Rep. 23(2):470-484.
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Annibaldi A †, Wicky John S*, Vanden Berghe T*, Swatek KN*, Ruan J, Liccardi G, Bianchi K, Elliott PR, Choi SM, Van Coillie S, Bertin J, Wu H, Komander D, Vandenabeele P, Silke J, Meier P †(2018). Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2. Mol Cell. 69(4):566-580.
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Xia S*, Fu TM*, Wu H† (2018). Inflammation NODs to Antagonists of RIP2-XIAP Interaction. Mol Cell. 69(4):535-536.
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Fu TM*, Shen C*, Li Q, Zhang P, Wu H† (2018). Mechanism of ubiquitin transfer promoted by TRAF6. Proc Natl Acad Sci U S A. 115(8):1783-1788.
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Zhang L, Wu H† (2018). Bad germs are trapped. Cell Res. 28(2):141-142
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Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC† (2018). The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Immunity. 48(1):35-44
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Wang L*, Qiao Q, Ferrao R*, Shen C, Hatcher JM, Buhrlage SJ, Gray NS, Wu H† (2017). Crystal structure of human IRAK1.​ Proc Natl Acad Sci U S A114(51):13507-13512
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Lamour G, Nassar R*, Chan PH*, Bozkurt G, Li J, Bui JM, Yip CK, Mayor T, Li H, Wu H, Jorg A. Gsponer† (2017). Mapping the Broad Structural and Mechanical Properties of Amyloid Fibrils. Biophys. 112(4):584-594
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Katja G. Weinacht*†, Louis-Marie Charbonnier*, Fayhan Alroqi, Ashley Plant, Qi Qiao, Hao Wu, Clement Ma, Troy R. Torgerson, Serogo D. Rosenzweig, Thomas A.Fleisher, Luigi D. Notarangelo, Imelda C. Hanson, Lisa R. Forbes, Talal A. Chatila (2017). Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation. Journal of Allergy and Clinical Immunology. 139(5):1629-1640
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Wu H*†, Fuxreiter M*† (2016). The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules. Cell. 165:1055-1066
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Zhang L*, Chen*, Jianbin R, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y†, Wu H† (2015). Cryo-EM structure of the activated NAIP2/NLRC4 Inflammasome reveals nucleated polymerization. Science. 350:404-9
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Ferrao R, Zhou H, Shan Y, Liu Q, Li Q, Shaw DE, Li X, Wu H† (2014). IRAK4 Dimerization and the Trans-autophosphorylation are Induced by Myddosome Assembly. Mol Cell. 55:891-903
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Lu A*, Magupalli VG*, Ruan J*, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitgerald KA, Wu H†, Egelman EH (2014). Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes. Cell. 6:1193-206
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Li L*†, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison T*. (2014). Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nat Chem Biol. 10:1043-8
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Jang TH, Zheng C, Li J, Richards C, Hsiao YS, Walz T, Wu H, Park HH†. (2014). Structural Study of the RIPosptosome core reveals a helical assembly for kinase recruitment. Biochemistry. 53:5424-31
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Ru H*, Zhang P*, Wu H†. (2014). Promiscuity is not Always Bad. Mol Cell. 2:208-9
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Furman RR*, Cheng S*, Lu P*, Setty M, Perez AR, Guo A, Racchumi J, Xu G, Wu H, Ma J, Steggerda SM, Coleman M, Leslie C, Wang YL. (2014). Ibrutinib Resistance in Chronic Lymphocytic Leukemia. N Engl J Med. 24:2352-4
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Lu A, Kavaleeswaran V, Fu T, Magupalli VG, Wu H†. (2014). Crystal Structure of the F27G AIM2 PYD Mutant and Similarities of Its Self-Association to DED/DED Interactions. J Mol Biol. 7:1420-7
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Qiao Q*, Yang C*, Zheng C*, Fontan L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman E, Wu H† (2013). Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly.​ Mol Cell. 51:766-779
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Yin Q*, Sester DP*, Tian Y*, Hsiao YS, Lu A, Cridlan JA, Sagulenko V, Thygesen SJ, Chouhey D, Hornung V, Walz T, Stacey KJ†, Wu H† (2013). Molecular Mechanism for p202-mediated Specific Inhibition of AIM2 Inflammasome Activation. Cell Reports. 4:327-39
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Lee JH*, Yi L*, Li J, Schweitzer K, Borgmann M, Naumann M, Wu H† (2013). Crystal Structure and Versatile Functional Roles of the COP9 Signalsome Subunit 1. Proceedings of the National Academy of Sciences. 110:11845-50
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Wu H† (2013). Higher-Order Assemblies in a New Paradigm of Signal Transduction. Cell. 153:287-292
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Yang C†, David L, Qiao Q, Damko E, Wu H. (2013). The CBM Signalosome: Potential Therapeutic Target for Aggressive Lymphoma? Cytokine Growth Factor Rev. 2:175-183
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Kim S*, Li L*, Maliga Z, Yin Q, Wu H, Mitchison T†. (2013). Anticancer Flavonoids Are Mouse-Selective STING Agonists. ACS Chemical Biology. 8:1396-1401
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Li J*, Yin Q*, Wu H†. (2013). Structural Basis of Signal Transduction in the TNF Receptor Superfamily. Advanced Immunology. 119:135-53
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Napteschnig J, Wu H†. (2013). Molecular Basis of NF-kB signaling. Annual Reviews in Biophysics. 42:443-68
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Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, Agelidis A, Shifrin N, Advincula R, Barrera J, Malynn BA, Wu H, Ma A†. (2013). Dimerization and Ubiquitin Mediated Recruitment of A20, a Complex Deubiquitinating Enzyme. Immunity. 38:1-10
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Yin Q†, Tian Y, Kabaleeswaran V, Jiang X, Tu D, Eck MJ, Chen ZJ, Wu H† (2012). Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol Cell. 46:735-45
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Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, Chan FK, Wu H† (2012). The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell. 150:339-50
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Ferrao R, Li J, Bergamin E, Wu H†. (2012). Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily. Sci Signal. 5:re3
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Ferrao R, Wu H†. (2012). Helical assembly in the death domain (DD) superfamily. Curr Opin Struct Biol. 22:241-7
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Feldman T, Kabaleeswaran V, Jang SB, Antczak C, Djaballah H, Wu H, Jiang X†. (2012). A class of allosteric caspase inhibitors identified by high-throughput screening. Mol Cell. 47:585-95
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Xu G*, Lo YC*, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H† (2011). Crystal structure of inhibitor of kappaB kinase beta. Nature. 472:325-330
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Wu H*, Siegel RM*. Medicine. (2011). Progranulin resolves inflammation. Science. 332:427-8
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Zheng C*, Yin Q*, Wu H†. (2011). Structural studies of NF-kB signaling. Cell Research. 21:183-959
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Wang L*, Yang J*, Kabaleeswaran V*, Rice A, Cruz A, Park A, Yin Q, Damko E, Jang S, Raunser S, Robinson C, Siegel R, Walz T, Wu H† (2010). The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nature Struct Mol Biol. 17:1324-9
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LLin SC, Lo YC, Wu H† (2010). Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signaling. Nature. 465: 885-90
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Zheng C, Kabaleeswaran V*, Wang Y*, Cheng G, Wu H† (2010). Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes -- affinity, specificity and regulation. Mol Cell. 38:101-13
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Wu H†, Lo YC, Lin SC. (2010). Recent advances in polyubiquitin chain recognition. F1000 Biol Reports. 2:1-5
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Lu M, Lin SC, Huang Y, Kang Y, Rich R, Lo YC, Myszka D, Han J, Wu H† (2007). XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Mol Cell. 26:689-702.
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Jiang X, Dreano M, Buckler D R, Cheng S, Ythier A, Wu H, W A Hendrickson, Tayar N E.† (1995). Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions. Structure. 3:1341-1353
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Lustbader J W, Wu H, Birken S, Pollak S, Kolks M A G, Pound A M, Austin D, Hendrickson W A, Canfield R E. (1995). The expression, characterization and crystallization of wild-type and selenomethionyl hCG. Endocrinology. 136:640-650
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Wu H, Lustbader J, Liu Y, Canfield R, Hendrickson W† (1994). Structure of human chorionic gonadotropin at 2.6 Å resolution from MAD analysis of the selenomethionyl protein. Structure. 2:545-558. (News & Views in Nature, 369: 438-439, 1994)
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Lustbader J W, Wang C, Zhang X, Birken S, Wu H, Brown J M, Yarmush D, Pollak S, Canfield R E. (1994). Human chorionic gonadotropin: progress in determining its tertiary structure. Glycoprotein hormones. pp 81-102. Springer-Verlag, New York
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Wu H, Keller W, Rossmann M G† (1993). Determination and refinement of the canine parvovirus empty capsid structure. Acta Crystallogr. D49:572-579
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Wu H, Rossmann M G.† (1993). The canine parvovirus empty capsid structure. J Mol Biol. 233: 231-244
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Tsao J, Chapman M S, Wu H, Agbandje M, Keller W, Rossmann M G. (1992). The structure determination of monoclinic canine parvovirus. Acta Crystallogr. B48:75-88
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Rossmann M G†, McKenna R, Tong L, Xia D, Dai J, Wu H, Choi H, Lynch R E. (1992). Molecular replacement real space averaging. J. Appl. Crystallogr. 25:166-180
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Gong Z X, Wu H, Cheng R H, Hull R, Rossmann M G† (1990). Crystallization of cauliflower mosaic virus. Virology. 179:941-5
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